Terns Pharmaceuticals Announces the Appointment of Erin Quirk, M.D., as Chief Medical Officer

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SAN MATEO, Calif., and SHANGHAI, China, January 17th, 2019 – Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly targeted, oral, small-molecule drugs to treat NASH and cancer, announced today the appointment of Erin Quirk, M.D. as Chief Medical Officer (CMO). Dr. Quirk brings more than two decades of clinical medicine and drug development experience, most recently serving as Vice President of Clinical Research at Gilead Sciences.

“Erin is a highly accomplished clinician with an extensive track record in developing and registering new treatments for infectious diseases and liver diseases. Her expertise will be invaluable as we advance our portfolio of NASH drugs, including TERN-101, TERN-201, and future pipeline candidates, through the clinic,” said Weidong Zhong, Ph.D., President and CEO of Terns. “We are delighted to have Erin join us at this critical time in our company’s growth, as her proven leadership and background in both early and late-stage drug development make her well suited to lead the growing Terns clinical development team.”

Dr. Quirk commented, “I am excited to be a part of this dedicated team focused on developing treatments for NASH, which currently has no approved treatments. I look forward to leveraging my clinical development background to advance these important drug candidates.”

Previously Dr. Quirk was Vice President, Clinical Research at Gilead Sciences where she oversaw all phases of clinical development for Gilead’s HIV treatment, prevention and cure franchise and was responsible for strategy and life-cycle maintenance for the company’s HIV portfolio, advancing multiple compounds and combination products into clinical development and through the approval process. She also led the clinical development of small molecules within Gilead’s emerging and neglected viral diseases portfolio, including antivirals for Ebola virus disease. Prior to joining Gilead, Dr. Quirk was Director of Clinical Research at Merck where she advanced clinical trials for Merck’s investigational HIV vaccine products and oversaw the clinical development of small molecules for hepatitis C virus infection. Dr. Quirk holds an MD from the University of Colorado and completed training in internal medicine and infectious diseases at Washington University in St. Louis where she was a faculty member prior to joining the pharmaceutical industry.

About Terns Pharmaceuticals

Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drugs that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs. Terns plans to focus initial development activities on regulatory approval in China and explore clinical development in additional global markets. For more information, visit www.TernsPharma.com.

US Media Contact:
Margaret Robinson
+(415)-690-0084

China Media Contact:
Eddy Wu
+ 86 180 1631 1449

Terns Pharmaceuticals Completes $80 Million Series B Financing to Advance Pipeline of Drugs to Treat NASH and Cancer

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Terns Pharmaceuticals Completes $80 Million Series B Financing to Advance Pipeline of Drugs to Treat NASH and Cancer
Proceeds to Support Development of Clinical and Preclinical NASH Candidates

Financing Led by Vivo Capital and OrbiMed, joined by Decheng Capital

Lilly Asia Ventures, the Series A investor, also investing in the Series B round

SAN MATEO, CA, and Shanghai, China, Oct 30th, 2018 – Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly targeted, oral, small-molecule drugs to treat NASH and cancer, today announced the closing of an $80 million Series B financing.
“Since we launched the company a short time ago, we have been working diligently to advance our key programs and continue executing on our strategy to bring innovative therapeutics to underserved patients globally, and with this financing we are well positioned to continue to execute on that mission,” said Weidong Zhong, Ph.D., President and CEO of Terns. “We are excited about the progress we’ve made on our clinical and preclinical programs. Our lead programs TERN-101 and TERN-201 are on track to enter the clinic in the first half of 2019 and additional NASH programs are advancing rapidly towards preclinical development. The progress so far has put us one step closer to our goal of discovering effective and safe combination therapies for patients with NASH and liver fibrosis. We are grateful for the confidence and enthusiasm coming from our new and existing investors.”
“Terns leverages a combination of expertise in disease biology, medicinal chemistry, and extensive clinical development capabilities to build its high-quality and diverse pipeline for the treatment of NASH, offering an incredible opportunity to bring potentially promising new therapies to patients,” said Mr. Shan Fu, Vivo Capital’s Managing Partner and Co-CEO. “We are excited to be co-leading a great group of investors and are believers in the novel approach Terns is taking. Vivo has substantial investment experience in the development of therapeutics for NASH. We believe that we will add value to the company in terms of its future development.”
“Their approach of adopting global or region-specific development strategies for advancing new clinical-stage therapeutics is unique, and Terns has made tremendous progress since they recently launched,” said Carl Gordon, Ph.D., Managing Partner of OrbiMed. “This gives us great confidence in their ability to successfully sustain that forward trajectory.”

The financing was led by new investors Vivo Capital and OrbiMed, joined by new investor Decheng Capital; existing investor Lilly Asia Ventures also participated to provide continuous support.

About Terns Pharmaceuticals
Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small-molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drug candidates that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs. For more information, visit www.TernsPharma.com

US Media Contact:
Cory Tromblee 617-571-7220
China Media Contact:
Eddy Wu
+ 86 180 1631 1449

Terns Pharmaceuticals Announces the Addition of Juan Carlos Lopez- Talavera, M.D., Ph.D. and Chuan Shih, Ph.D., as Scientific Advisors

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SAN MATEO, CA, and Shanghai, China, April 12, 2018 – Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly-targeted, oral, small molecule drugs to treat liver disease and cancer, announced today the addition of Juan Carlos Lopez-Talavera, M.D., Ph.D. and Chuan (Joe) Shih, Ph.D. as scientific advisors.

“As we prepare to enter the clinic with two lead compounds, TERN-101 and TERN-201, for the treatment of NASH in multiple markets, having Dr. Lopez-Talavera and Dr. Shih as resources will be invaluable,” said Weidong Zhong, Ph.D., President and CEO of Terns. “Their expertise in liver disease and oncology drug discovery and development is highly relevant and complimentary to that of our internal team and we have already started integrating them into their advisory function.”

Juan Carlos Lopez-Talavera, M.D., Ph.D.
Dr. Lopez-Talavera has over 20 years of experience in the biopharma industry, with extensive expertise in liver and gastrointestinal diseases. Most recently, Dr. Lopez-Talavera was Senior Vice President, Head of Medical Affairs and member of the Executive Team at Intercept Pharmaceuticals. Previously he held positions at AbbVie as Head of Medical Affairs, Global Research and Development, Bristol Myers Squibb, where he was Vice President and Global Development Lead, and at Roche Laboratories as Senior Medical Director. Before moving into industry, Dr. Lopez-Talavera was Assistant Professor with the Divisions of Gastroenterology and Hepatology, and Endocrinology and Pathology at the University of Pittsburgh Medical Center and Associate Professor of Medicine with the Universidad Autónoma de Barcelona and Attending Physician of the Liver Unit at the Hospital General Universitari Vall D’Hebron in Barcelona.

Dr. Lopez-Talavera was a Postdoctoral Fellow at the Yale University School of Medicine, and Clinical Observer at Sloan Kettering Memorial Cancer Center. He holds an M.D. and a Ph.D. in Hepatology from the Universidad Autónoma de Barcelona.

Chuan (Joe) Shih, Ph.D.
Dr. Shih is currently a Venture Partner of Lilly Asia Ventures with over 30 years of experience working within the life sciences industry. Before joining Lilly Asia Ventures, he was the Director of the Institute of Biotechnology and Pharmaceutical Research (IBPR) of the National Health Research Institutes (NHRI), a premier new drug discovery institute in Taiwan. Prior to IBPR, Dr. Shih led drug discovery and translational medicine teams across multiple therapeutic areas at Crown Biosciences, Inc. Lilly Research Laboratories and Eli Lilly and Company. Over his career, Dr. Shih has led discovery efforts that have resulted in or contributed to multiple successful commercial products. He received numerous achievement awards throughout his career including the 2006 American Chemical Society “Heroes of Chemistry” Award for his role in the discovery and development of Alimta®.

Dr. Shih received his Ph.D. in organic chemistry from Ohio State University. He completed a postdoctoral fellowship at Harvard University under Nobel Laureate Professor E. J. Corey.

About Terns Pharmaceuticals
Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drugs that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs.

US Media Contact:
Cory Tromblee
617-571-7220

China Media Contact:
Eddy Wu
+ 86 180 1631 1449

Terns Pharmaceuticals Acquires Global, Exclusive Rights to Develop and Commercialize Three NASH Assets from Lilly

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Deal Includes an FXR Agonist, an SSAO Inhibitor and An Additional Candidate Against a Well-Validated NASH Target

Development of Clinical Programs Will Focus on Regulatory Approval in China and Additional Global Markets

SAN MATEO, Calif. ‐ Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer, announced today it has signed a global, exclusive license agreement with Eli Lilly and Company to develop, manufacture and commercialize three small molecule therapeutic candidates for the potential treatment of non-alcoholic steatohepatitis (NASH). The agreement includes a clinical stage farnesoid X receptor (FXR) agonist, TERN-101, a semicarbazide-sensitive amine oxidase (SSAO) inhibitor, TERN-201, which is nearing IND submission, and a preclinical candidate that inhibits an undisclosed, well-validated NASH target. Terns Pharmaceuticals plans to focus initial development activities on regulatory approval in China and explore clinical development in additional global markets.

“We are excited about this agreement with Lilly, as it perfectly fits our strategy of bringing innovative therapeutics to underserved patients globally,” said Weidong Zhong, Ph.D., President and CEO of Terns. “The addition of these candidates to our current portfolio of discovery projects provides Terns with a fully integrated preclinical and clinical pipeline of products targeting both NASH and cancer. This also positions us well to investigate combination therapies early during clinical development to identify the best treatment regimens for NASH.”

“We are pleased to enter into this agreement with Terns Pharmaceuticals as we work to further our shared goal of making medicines to help people live longer, healthier, more active lives,” said Ruth Gimeno, Ph.D., Vice President, Diabetes Research and Clinical Investigation at Lilly. “We are committed to improving the lives of people affected with diabetes, and we view NASH as an important comorbidity and complication of diabetes. The experience of Terns in drug discovery and clinical development for liver disease in China will complement our internal research efforts and will be critical as these potential medicines are further developed in China and around the world.”

Farnesoid X Receptor (FXR) Agonism and TERN-101
FXR is a nuclear receptor expressed in high amounts in the liver and small intestine. Bile acids (BA) are natural ligands of FXR, and their binding with and activation of FXR is critical to the regulation of cellular pathways that modulate BA synthesis, lipid metabolism, inflammation and fibrosis. It is believed by many in the scientific community that FXR agonism and activation has potential as a new treatment modality for nonalcoholic fatty liver disease (NAFLD) and non- alcoholic steatohepatitis (NASH). TERN-101 is a potent non-bile acid FXR agonist being developed as a therapeutic for NASH.

Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibition and TERN-201
SSAO, also known as vascular adhesion protein-1 (VAP-1), is a dual-function amine oxidase which promotes recruitment of white blood cells in the liver, and can result in increased oxidative stress, inflammation and hepatic fibrosis. The level of surface SSAO is upregulated in the vasculature of inflamed tissues, and soluble SSAO levels are elevated in patients with NASH. Inhibition of SSAO is believed to have therapeutic benefit for the treatment of NAFLD, NASH and other chronic fibrotic liver diseases. TERN-201 is a potent SSAO inhibitor which provides an additional treatment mechanism for NASH by reducing oxidative stress and recruitment of white blood cells to the liver.

About NASH
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), which is caused by the accumulation of excess fat in the liver. NASH is associated with chronic liver inflammation and liver cell injury, and it can lead to fibrosis, cirrhosis and eventually liver cancer or liver failure. Global rates of NAFLD and NASH are increasing rapidly, in tandem with rising rates of obesity. It is estimated that 15 percent of the Chinese adult population has NAFLD. Of those patients, an estimated 20 percent will develop NASH. There is currently no approved medication for the treatment of NASH.

About Terns Pharmaceuticals
Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drugs that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs. Terns plans to focus initial development activities on regulatory approval in China and explore clinical development in additional global markets. For more information, visit www.TernsPharma.com.

 

Contacts
Terns Pharmaceuticals Inc.

US Media Contact
Cory Tromblee, 617-571-7220 or

China Media Contact
Eddy Wu, +86 ‭180 1631 1449‬