Terns Pharmaceuticals Announces the Addition of Juan Carlos Lopez- Talavera, M.D., Ph.D. and Chuan Shih, Ph.D., as Scientific Advisors

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SAN MATEO, CA, and Shanghai, China, April 12, 2018 – Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly-targeted, oral, small molecule drugs to treat liver disease and cancer, announced today the addition of Juan Carlos Lopez-Talavera, M.D., Ph.D. and Chuan (Joe) Shih, Ph.D. as scientific advisors.

“As we prepare to enter the clinic with two lead compounds, TERN-101 and TERN-201, for the treatment of NASH in multiple markets, having Dr. Lopez-Talavera and Dr. Shih as resources will be invaluable,” said Weidong Zhong, Ph.D., President and CEO of Terns. “Their expertise in liver disease and oncology drug discovery and development is highly relevant and complimentary to that of our internal team and we have already started integrating them into their advisory function.”

Juan Carlos Lopez-Talavera, M.D., Ph.D.
Dr. Lopez-Talavera has over 20 years of experience in the biopharma industry, with extensive expertise in liver and gastrointestinal diseases. Most recently, Dr. Lopez-Talavera was Senior Vice President, Head of Medical Affairs and member of the Executive Team at Intercept Pharmaceuticals. Previously he held positions at AbbVie as Head of Medical Affairs, Global Research and Development, Bristol Myers Squibb, where he was Vice President and Global Development Lead, and at Roche Laboratories as Senior Medical Director. Before moving into industry, Dr. Lopez-Talavera was Assistant Professor with the Divisions of Gastroenterology and Hepatology, and Endocrinology and Pathology at the University of Pittsburgh Medical Center and Associate Professor of Medicine with the Universidad Autónoma de Barcelona and Attending Physician of the Liver Unit at the Hospital General Universitari Vall D’Hebron in Barcelona.

Dr. Lopez-Talavera was a Postdoctoral Fellow at the Yale University School of Medicine, and Clinical Observer at Sloan Kettering Memorial Cancer Center. He holds an M.D. and a Ph.D. in Hepatology from the Universidad Autónoma de Barcelona.

Chuan (Joe) Shih, Ph.D.
Dr. Shih is currently a Venture Partner of Lilly Asia Ventures with over 30 years of experience working within the life sciences industry. Before joining Lilly Asia Ventures, he was the Director of the Institute of Biotechnology and Pharmaceutical Research (IBPR) of the National Health Research Institutes (NHRI), a premier new drug discovery institute in Taiwan. Prior to IBPR, Dr. Shih led drug discovery and translational medicine teams across multiple therapeutic areas at Crown Biosciences, Inc. Lilly Research Laboratories and Eli Lilly and Company. Over his career, Dr. Shih has led discovery efforts that have resulted in or contributed to multiple successful commercial products. He received numerous achievement awards throughout his career including the 2006 American Chemical Society “Heroes of Chemistry” Award for his role in the discovery and development of Alimta®.

Dr. Shih received his Ph.D. in organic chemistry from Ohio State University. He completed a postdoctoral fellowship at Harvard University under Nobel Laureate Professor E. J. Corey.

About Terns Pharmaceuticals
Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drugs that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs.

US Media Contact:
Cory Tromblee
617-571-7220

China Media Contact:
Eddy Wu
+ 86 180 1631 1449

Terns Pharmaceuticals Acquires Global, Exclusive Rights to Develop and Commercialize Three NASH Assets from Lilly

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Deal Includes an FXR Agonist, an SSAO Inhibitor and An Additional Candidate Against a Well-Validated NASH Target

Development of Clinical Programs Will Focus on Regulatory Approval in China and Additional Global Markets

SAN MATEO, Calif. ‐ Terns Pharmaceuticals Inc., a global biopharmaceutical company focused on discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer, announced today it has signed a global, exclusive license agreement with Eli Lilly and Company to develop, manufacture and commercialize three small molecule therapeutic candidates for the potential treatment of non-alcoholic steatohepatitis (NASH). The agreement includes a clinical stage farnesoid X receptor (FXR) agonist, TERN-101, a semicarbazide-sensitive amine oxidase (SSAO) inhibitor, TERN-201, which is nearing IND submission, and a preclinical candidate that inhibits an undisclosed, well-validated NASH target. Terns Pharmaceuticals plans to focus initial development activities on regulatory approval in China and explore clinical development in additional global markets.

“We are excited about this agreement with Lilly, as it perfectly fits our strategy of bringing innovative therapeutics to underserved patients globally,” said Weidong Zhong, Ph.D., President and CEO of Terns. “The addition of these candidates to our current portfolio of discovery projects provides Terns with a fully integrated preclinical and clinical pipeline of products targeting both NASH and cancer. This also positions us well to investigate combination therapies early during clinical development to identify the best treatment regimens for NASH.”

“We are pleased to enter into this agreement with Terns Pharmaceuticals as we work to further our shared goal of making medicines to help people live longer, healthier, more active lives,” said Ruth Gimeno, Ph.D., Vice President, Diabetes Research and Clinical Investigation at Lilly. “We are committed to improving the lives of people affected with diabetes, and we view NASH as an important comorbidity and complication of diabetes. The experience of Terns in drug discovery and clinical development for liver disease in China will complement our internal research efforts and will be critical as these potential medicines are further developed in China and around the world.”

Farnesoid X Receptor (FXR) Agonism and TERN-101
FXR is a nuclear receptor expressed in high amounts in the liver and small intestine. Bile acids (BA) are natural ligands of FXR, and their binding with and activation of FXR is critical to the regulation of cellular pathways that modulate BA synthesis, lipid metabolism, inflammation and fibrosis. It is believed by many in the scientific community that FXR agonism and activation has potential as a new treatment modality for nonalcoholic fatty liver disease (NAFLD) and non- alcoholic steatohepatitis (NASH). TERN-101 is a potent non-bile acid FXR agonist being developed as a therapeutic for NASH.

Semicarbazide-Sensitive Amine Oxidase (SSAO) Inhibition and TERN-201
SSAO, also known as vascular adhesion protein-1 (VAP-1), is a dual-function amine oxidase which promotes recruitment of white blood cells in the liver, and can result in increased oxidative stress, inflammation and hepatic fibrosis. The level of surface SSAO is upregulated in the vasculature of inflamed tissues, and soluble SSAO levels are elevated in patients with NASH. Inhibition of SSAO is believed to have therapeutic benefit for the treatment of NAFLD, NASH and other chronic fibrotic liver diseases. TERN-201 is a potent SSAO inhibitor which provides an additional treatment mechanism for NASH by reducing oxidative stress and recruitment of white blood cells to the liver.

About NASH
Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), which is caused by the accumulation of excess fat in the liver. NASH is associated with chronic liver inflammation and liver cell injury, and it can lead to fibrosis, cirrhosis and eventually liver cancer or liver failure. Global rates of NAFLD and NASH are increasing rapidly, in tandem with rising rates of obesity. It is estimated that 15 percent of the Chinese adult population has NAFLD. Of those patients, an estimated 20 percent will develop NASH. There is currently no approved medication for the treatment of NASH.

About Terns Pharmaceuticals
Based in San Mateo, CA., and Shanghai, China, Terns Pharmaceuticals is a global biopharmaceutical company committed to discovering and developing molecularly targeted, oral, small molecule drugs to treat liver disease and cancer. The company combines expertise in disease biology, medicinal chemistry and extensive clinical development capabilities in China to advance its growing pipeline of drugs that are optimized against clinically validated targets or targets that have significant preclinical validation. Using a capital-efficient drug discovery model, the company’s mission is to bring promising new therapies to patients in underserved markets via global and region-specific development programs. Terns plans to focus initial development activities on regulatory approval in China and explore clinical development in additional global markets. For more information, visit www.TernsPharma.com.

 

Contacts
Terns Pharmaceuticals Inc.

US Media Contact
Cory Tromblee, 617-571-7220 or

China Media Contact
Eddy Wu, +86 ‭180 1631 1449‬